Degree of corneal anaesthesia after topical application of 0.4% oxybuprocaine hydrochloride and 0.5%proparacaine hydrochloride ophthalmic solution in clinically normal cattle.

St Kitts – mechentel news – The use of corneal anaesthesia is necessary for a range of clinical purposes. Therefore, we assessed and compared the efficacy of corneal anaesthesia after application of 0.4% oxybuprocaine hydrochloride and 0.5% proparacaine hydrochloride ophthalmic solution inclinically normal cattle.The 24 clinically normal cows were allocated into two groups. Cows in group 1 (n = 12) received 0.2 mL of 0.4% oxybuprocainehydrochloride with fluorescein ophthalmic solution in one eye and 0.2 mL of sterile saline (0.9% NaCl) with fluorescein in the contralateral eye (control). Group 2 (n = 12) received 0.2 mL of 0.4% oxybuprocaine hydrochloride with fluorescein ophthalmic solution in one eye and 0.2 mL of0.5% proparacaine hydrochloride with fluorescein in the contralateral eye (control). In each group, corneal touch threshold was determined by Cochet-Bonnet aesthesiometer for both eyes immediately prior to topical administration of solutions, at 1 min and 5 min after administration oftopical solutions and every 5 min thereafter for a total of 75 min. Significant corneal anaesthesia was noted immediately following topical application of both oxybuprocaine and proparacaine as compared with controls, with maximal corneal anaesthesia noted 1 min after administration. Both oxybuprocaine and proparacaine produced significant corneal anaesthesia for the duration of the 75-min study. Neither oxybuprocaine hydrochloride nor proparacaine hydrochloride treatment resulted in visible adverse effects. There are limited data available demonstrating the efficacy and duration of corneal anaesthetic agents in cattle. Bothoxybuprocaine hydrochloride and proparacaine hydrochloride should be considered practical options for providing corneal anaesthesia in cattle in a clinical setting. (pubmed, mm)

Autoren: Little WB, Jean GS, Sithole F, Little E, Jean KY. Korrespondenz: Department of Clinical Sciences, Ross University College of Veterinary Medicine, Island Main Road, West farm, St Kitts 00265, West Indies. E-Mail: brlittle@rossvet.edu.kn. Studie: Degree of corneal anaesthesia after topical application of 0.4% oxybuprocaine hydrochloride and 0.5% proparacaine hydrochloride ophthalmic solution in clinically normal cattle. Quelle: Aust Vet J. 2016 Jun;94(6):181-5. doi: 10.1111/avj.12443. Web: http://onlinelibrary.wiley.com/doi/10.1111/avj.12443/abstract