Tissue ingrowth without growth of multinucleated giant cells
Sao Paulo – mechentel news – Perforated acrylic implants permit tissue ingrowth, so Ph.D. D. Miyashita et al. of the Department of Ophthalmology, University of Sao Paulo. The purpose was to evaluate the clinical response and fibrovascular ingrowth into perforated acrylic orbital implants in a rabbit model. Perforated implants were manufactured by drilling channels interconnected at the center in conventional 12- to 13-mm acrylic spheres. The implants were placed in 16 eviscerated eyes with posterior sclerotomy of 16 New Zealand white rabbits. Clinical evaluation was performed daily for the first 14 days after surgery and at 7-day intervals until the end of the study (180 days). Histopathologic analysis was performed at 14, 45, 90, and 180 days after implantation. Hematoxylin-eosin and picrosirius red staining was used to assess the inflammatory reaction and collagen formation. There were no signs of infection, implant exposure, or extrusion in any animal during the study, said the scientists in the February 2013 issue of the journl Ophthalmology. Tissue ingrowth in the implant center was already detected by 14 days. At the end of the study, there was a dense collagen ingrowth with just a few inflammatory cells inside the implant. No multinucleated giant cells were found in any implant.
Authors: Miyashita D, Chahud F, Silva GE, Albuquerque VB, Garcia DM, Cruz AA. Correspondence: Department
of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas-Campus,
School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto; and †Department of
Anesthesiology, Surgery, Hospital das Clínicas-Campus, School of Veterinary, University of State São Paulo,
Araçatuba, São Paulo, Brazil. Study: Tissue Ingrowth Into Perforated Polymethylmethacrylate Orbital
Implants in 16 New Zealand white rabbits: An Experimental Study. Source: Ophthal Plast Reconstr Surg.
2013 Feb 26. Web: http://journals.lww.com/op-rs/Abstract/publishahead/Tissue_Ingrowth_Into_Perforated.